ALnox  [ Back to  Medical Gases  ]

ALnoxTM is a premixed medical gas composed of 50% Nitrous Oxide and 50% Oxygen.

ALnox Overview

A mixture of 50% Nitrous Oxide and 50% Oxygen is an analgesic drug. It delivers safe sedation(2) and analgesia for elective diagnostics and therapeutic procedures involving significant anxiety or pain in adults or children. It does not provide any anaesthetic effect or respiratory drive depression. It does not cause loss of consciousness and the laryngeal closure reflex is maintained(3). It is very well tolerated(2) and with 50% Oxygen there is a minimized risk of hypoxia. It has a short withdrawal time; the effects disappear in 1 to 3 minutes(1).

Administration

For use by or under the supervision of a licensed Medical or Dental Practitioner. ALnox is directly inhaled via a mask or a mouthpiece from a cylinder containing the mixture. Self-administration is safe and convenient for both the patient and practitioner.

Duration

ALnoxTM has a very fast onset of action and short withdrawal time of 1– 3 minutes(1). It can be used up to one hour of continuous use and can also be used daily for up to 15 days.

Contraindications

ALnoxTM is contraindicated in un-evaluated cranial trauma, altered consciousness, intracranial hypertension, gaseous emboli, emphysema, following a diving accident, with maxillofacial injury preventing the airtight placement of the mask on the face, undrained pneumothorax, recent eye surgery involving gaseous tamponade or gastric or abdominal distension. Equilibration of the partial pressures of nitrous oxide between the blood and air filled spaces causes rapid expansion in these cavities. The gas should not be used at temperatures under –5°C.

Focus on ALnox applications

Medical Gas

ALnox kit

ALnox Administration kit : Demand valve

Studies on 50:50 Nitrous Oxide and Oxygen

(1) Pons PT. Nitrous oxide analgesia. Emergency Medicine Clinics of North America 1988;6:777-82.

(2) Onody P. et al. Safety of inhalation of 50% Nitrous Oxide/Oxygen Premix. Drug Safety 2006; 29(7):633- 40

(3) Cleaton-Jones P. The laryngeal-closure reflex and nitrous oxide-oxygen analgesia. Anesthesiology 1976; 45: 569-70.

(4) Dula DJ. Nitrous oxide analgesia. In Roberts J, Hedges JWB, eds. Clinical procedures in emergency medicine. Second edition. Philadelphia : WB Saunders Company ; 1991. p 508-14.

(5) Roberts GJ, Wignall BK. Efficacy of the laryngeal reflex during oxygen-nitrous oxide sedation. Br J Anaesth 1982;54:1277-81.

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